Pair Name	Nimbolide, Tumor necrosis factor-alpha
Partner Name	Nimbolide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BID	hsa637
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	Our findings overall indicate that nimbolide may enhance TNF-α-mediated cellular proliferation inhibition through increasing cell apoptosis of HT-29 cells by up-reglation of DR5 expression via the JNK pathway.

Pair Name	Helichrysetin, Tumor necrosis factor-alpha
Partner Name	Helichrysetin
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Activity	CASP3	hsa836
	Down-regulation	Phosphorylation	CHUK	hsa1147
	Down-regulation	Phosphorylation	EGFR	hsa1956
	Down-regulation	Phosphorylation	NR2C2	hsa7182
	Up-regulation	Activity	PARP1	hsa142
	Down-regulation	Phosphorylation	RELA	hsa5970
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
	T98G	Glioblastoma	Homo sapiens (Human)	CVCL_0556
Result	Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer.